Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression
نویسندگان
چکیده
منابع مشابه
Cooperative DNA binding by a splice variant of the transcription factor ETS1 that lacks autoinhibition
ETS1 is the archetypal member of the metazoan ETS transcription factor family. All the members of this family bind to the conserved GGA(A/T) core ETS binding sequence (EBS). Several ETS family members exhibit autoinhibition, wherein one domain of ETS blocks its own DNA-binding activity until certain conditions are met. Relief of autoinhibition in these proteins is coupled to homoor hetero-dimer...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2015
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2015.03.002